Oprah Winfrey is on the cover of TV Guide and dishes about her last season on 'The Oprah Winfrey Show' Gina DiFalco Oprah Winfrey is embarking upon her last year hosting The Oprah Winfrey Show after a 25-year run. USA Today reports that Winfrey graces the newest edition of TV Guide, alongside Dr. Phil, Dr. Oz, and Nate Berkus and opens up about her departure from daytime TV as well as what her ...